CAR T Cell Therapy Step-by-Step
Step 3: Your Treatment
Lymphodepleting Chemotherapy
Depending on your disease and the CAR T therapy you are receiving, you will receive chemotherapy prior to your CAR T infusion. This chemotherapy is commonly known as lymphodepleting chemotherapy and helps prepare your body for the CAR T cells.
Depending on your CAR T treatment center as well as aspects of your specific disease, your doctor will decide whether you will receive your treatment in an inpatient or an outpatient setting.
CAR T Cell Therapy Infusion Process
Your CAR T cell therapy healthcare team will let you know the details about your CAR T treatment such as the date of infusion and when to arrive at the treatment center. CAR T cell infusion typically occurs a few days after lymphodepleting chemotherapy. The steps of the infusion process are outlined below.
Your Team
May consist of:
- Medical Oncologist
- Specialized Nurse(s)
- Care Partner
Estimated Duration
- Lymphodepleting Chemotherapy: 3-4 days
- Infusion: ≥1 hour
- Your CAR T cells will be stored until the start of your infusion. Prior to the infusion, you may receive medications, such as diphenhydramine, to reduce the risk of an allergic reaction.
- Your CAR T cells will be infused via an IV line and they may be in an infusion bag or a syringe, depending on the product.
- The infusion time varies, but can usually be completed over the course of 1 hour.
- The day you receive your CAR T cells, you may remain in the hospital or be discharged, depending on what you and your doctor decide is best.
- You will require frequent monitoring or check-ins immediately after CAR T infusion.
How You Can Prepare
To prepare for the CAR T cell therapy infusion process, consider asking your treatment center or CAR T cell therapy manufacturer about the availability of educational resources and/or support programs that may include financial assistance with lodging, transportation, and meals. Resources and financial support may vary by product manufacturer and eligibility requirements may apply.
Your Resources
Learn more about the CAR T cell therapy treatment process and possible side effects in this step-by-step guide.